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Cooperative PSGL-1 and CXCR2 signaling in neutrophils promotes deep vein thrombosis in mice

Inflammation is a major contributor to deep vein thrombosis (DVT). Flow restriction of the inferior vena cava (IVC) in mice induces DVT like that in humans. In this model, P-selectin–dependent adhesion of neutrophils and monocytes leads to release of neutrophil extracellular traps (NETs) and express...

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發表在:Blood
Main Authors: Yago, Tadayuki, Liu, Zhenghui, Ahamed, Jasimuddin, McEver, Rodger P.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161769/
https://ncbi.nlm.nih.gov/pubmed/30068506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-05-850859
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