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Th1 cells rolling on selectins trigger DAP12-dependent signals that activate integrin αLβ2
During inflammation, both neutrophils and effector T cells use selectins to roll and integrins to arrest in postcapillary venules. In both cell types, chemokines can transduce signals that convert integrin αLβ2 to a high-affinity conformation, which interacts with ICAM-1 to mediate arrest. In neutro...
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| Veröffentlicht in: | J Immunol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6920551/ https://ncbi.nlm.nih.gov/pubmed/31757864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900680 |
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