Th1 cells rolling on selectins trigger DAP12-dependent signals that activate integrin αLβ2

During inflammation, both neutrophils and effector T cells use selectins to roll and integrins to arrest in postcapillary venules. In both cell types, chemokines can transduce signals that convert integrin αLβ2 to a high-affinity conformation, which interacts with ICAM-1 to mediate arrest. In neutro...

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Bibliographic Details
Published in:	J Immunol
Main Authors:	Shao, Bojing, Yago, Tadayuki, Panicker, Sumith R., Zhang, Nan, Liu, Zhenghui, McEver, Rodger P.
Format:	Artigo
Language:	Inglês
Published:	2019
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6920551/ https://ncbi.nlm.nih.gov/pubmed/31757864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900680
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Th1 cells rolling on selectins trigger DAP12-dependent signals that activate integrin αLβ2

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