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Replacing the Promoter of the Murine Gene Encoding P-selectin with the Human Promoter Confers Human-like Basal and Inducible Expression in Mice

In humans and mice, megakaryocytes/platelets and endothelial cells constitutively synthesize P-selectin and mobilize it to the plasma membrane to mediate leukocyte rolling during inflammation. TNF-α, interleukin 1β, and LPS markedly increase P-selectin mRNA in mice but decrease P-selectin mRNA in hu...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Liu, Zhenghui, Zhang, Nan, Shao, Bojing, Panicker, Sumith R., Fu, Jianxin, McEver, Rodger P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714226/
https://ncbi.nlm.nih.gov/pubmed/26631722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.702126
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