Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G

The HIV-1-envelope (Env) trimer is covered by a glycan shield of ~90 N-linked oligosaccharides, which comprises roughly half its mass and is a key component of HIV evasion from humoral immunity. To understand how antibodies can overcome the barriers imposed by the glycan shield, we crystallized full...

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Publicado no:Cell
Main Authors: Stewart-Jones, Guillaume B. E., Soto, Cinque, Lemmin, Thomas, Chuang, Gwo-Yu, Druz, Aliaksandr, Kong, Rui, Thomas, Paul V., Wagh, Kshitij, Zhou, Tongqing, Behrens, Anna-Janina, Bylund, Tatsiana, Choi, Chang W., Davison, Jack R., Georgiev, Ivelin S., Joyce, M. Gordon, Do Kwon, Young, Pancera, Marie, Taft, Justin, Yang, Yongping, Zhang, Baoshan, Shivatare, Sachin S., Shivatare, Vidya S., Lee, Chang-Chun D., Wu, Chung-Yi, Bewley, Carole A., Burton, Dennis R., Koff, Wayne C., Connors, Mark, Crispin, Max, Baxa, Ulrich, Korber, Bette T., Wong, Chi-Huey, Mascola, John R., Kwong, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543418/
https://ncbi.nlm.nih.gov/pubmed/27114034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.04.010
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