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Hitting the sweet spot: Exploiting HIV-1 glycan shield for induction of broadly neutralizing antibodies

PURPOSE OF REVIEW: The surface of the HIV-1 Env glycoprotein, the target of neutralizing antibodies, is extensively covered by N-linked glycans that create a glycan shield. Broadly neutralizing antibodies (bNAbs), the primary targets of HIV-1 vaccine design, have to negotiate this glycan shield. Her...

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Bibliographic Details
Published in:Curr Opin HIV AIDS
Main Authors: Wagh, Kshitij, Hahn, Beatrice H., Korber, Bette
Format: Artigo
Language:Inglês
Published: 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877895/
https://ncbi.nlm.nih.gov/pubmed/32675574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/COH.0000000000000639
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