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Hitting the sweet spot: Exploiting HIV-1 glycan shield for induction of broadly neutralizing antibodies

PURPOSE OF REVIEW: The surface of the HIV-1 Env glycoprotein, the target of neutralizing antibodies, is extensively covered by N-linked glycans that create a glycan shield. Broadly neutralizing antibodies (bNAbs), the primary targets of HIV-1 vaccine design, have to negotiate this glycan shield. Her...

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Dades bibliogràfiques
Publicat a:Curr Opin HIV AIDS
Autors principals: Wagh, Kshitij, Hahn, Beatrice H., Korber, Bette
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877895/
https://ncbi.nlm.nih.gov/pubmed/32675574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/COH.0000000000000639
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