Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth

Platelet-derived microparticles (PMPs) are associated with enhancement of metastasis and poor cancer outcomes. Circulating PMPs transfer platelet microRNAs (miRNAs) to vascular cells. Solid tumor vasculature is highly permeable, allowing the possibility of PMP–tumor cell interaction. Here, we show t...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Michael, James V., Wurtzel, Jeremy G. T., Mao, Guang Fen, Rao, A. Koneti, Kolpakov, Mikhail A., Sabri, Abdelkarim, Hoffman, Nicholas E., Rajan, Sudarsan, Tomar, Dhanendra, Madesh, Muniswamy, Nieman, Marvin T., Yu, Johnny, Edelstein, Leonard C., Rowley, Jesse W., Weyrich, Andrew S., Goldfinger, Lawrence E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542851/
https://ncbi.nlm.nih.gov/pubmed/28500171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-11-751099
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