Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets

Human platelets contain microRNAs (miRNAs) and miRNA processing machinery, but their contribution to platelet function remains incompletely understood. Here, we show that murine megakaryocyte (MK)-specific knockdown of Dicer1, the ribonuclease that cleaves miRNA precursors into mature miRNAs, reduce...

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Pubblicato in:Blood
Autori principali: Rowley, Jesse W., Chappaz, Stéphane, Corduan, Aurélie, Chong, Mark M. W., Campbell, Robert, Khoury, Amanda, Manne, Bhanu Kanth, Wurtzel, Jeremy G. T., Michael, James V., Goldfinger, Lawrence E., Mumaw, Michele M., Nieman, Marvin T., Kile, Benjamin T., Provost, Patrick, Weyrich, Andrew S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2016
Soggetti:
Plenary Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825412/
https://ncbi.nlm.nih.gov/pubmed/26773046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-07-661371
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