Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets

Human platelets contain microRNAs (miRNAs) and miRNA processing machinery, but their contribution to platelet function remains incompletely understood. Here, we show that murine megakaryocyte (MK)-specific knockdown of Dicer1, the ribonuclease that cleaves miRNA precursors into mature miRNAs, reduce...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Rowley, Jesse W., Chappaz, Stéphane, Corduan, Aurélie, Chong, Mark M. W., Campbell, Robert, Khoury, Amanda, Manne, Bhanu Kanth, Wurtzel, Jeremy G. T., Michael, James V., Goldfinger, Lawrence E., Mumaw, Michele M., Nieman, Marvin T., Kile, Benjamin T., Provost, Patrick, Weyrich, Andrew S.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2016
Matèries:
Plenary Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825412/
https://ncbi.nlm.nih.gov/pubmed/26773046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-07-661371
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