Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets

Human platelets contain microRNAs (miRNAs) and miRNA processing machinery, but their contribution to platelet function remains incompletely understood. Here, we show that murine megakaryocyte (MK)-specific knockdown of Dicer1, the ribonuclease that cleaves miRNA precursors into mature miRNAs, reduce...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Rowley, Jesse W., Chappaz, Stéphane, Corduan, Aurélie, Chong, Mark M. W., Campbell, Robert, Khoury, Amanda, Manne, Bhanu Kanth, Wurtzel, Jeremy G. T., Michael, James V., Goldfinger, Lawrence E., Mumaw, Michele M., Nieman, Marvin T., Kile, Benjamin T., Provost, Patrick, Weyrich, Andrew S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825412/
https://ncbi.nlm.nih.gov/pubmed/26773046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-07-661371
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