Increase of MET gene copy number confers resistance to a monovalent MET antibody and establishes drug dependence

The relevant role in cancer played by the tyrosine kinase receptor encoded by the MET oncogene led to the development of specific inhibitors, some of which are now in advanced phases of clinical trials. Previous experience has shown that the main limit to the efficacy of most targeted treatments is...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Martin, Valentina, Corso, Simona, Comoglio, Paolo M., Giordano, Silvia
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2014
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528600/
https://ncbi.nlm.nih.gov/pubmed/25011627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.06.010
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