Monovalency Unleashes the Full Therapeutic Potential of the DN-30 Anti-Met Antibody

Met, the high affinity receptor for hepatocyte growth factor, is one of the most frequently activated tyrosine kinases in human cancer and a validated target for cancer therapy. We previously developed a mouse monoclonal antibody directed against the extracellular portion of Met (DN-30) that induces...

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Detalhes bibliográficos
Main Authors: Pacchiana, Giovanni, Chiriaco, Cristina, Stella, Maria C., Petronzelli, Fiorella, De Santis, Rita, Galluzzo, Maria, Carminati, Paolo, Comoglio, Paolo M., Michieli, Paolo, Vigna, Elisa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975237/
https://ncbi.nlm.nih.gov/pubmed/20833723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.134031
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