Monovalency Unleashes the Full Therapeutic Potential of the DN-30 Anti-Met Antibody

Met, the high affinity receptor for hepatocyte growth factor, is one of the most frequently activated tyrosine kinases in human cancer and a validated target for cancer therapy. We previously developed a mouse monoclonal antibody directed against the extracellular portion of Met (DN-30) that induces...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Pacchiana, Giovanni, Chiriaco, Cristina, Stella, Maria C., Petronzelli, Fiorella, De Santis, Rita, Galluzzo, Maria, Carminati, Paolo, Comoglio, Paolo M., Michieli, Paolo, Vigna, Elisa
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Signal Transduction
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975237/
https://ncbi.nlm.nih.gov/pubmed/20833723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.134031
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