Inhibition of ligand‐independent constitutive activation of the Met oncogenic receptor by the engineered chemically‐modified antibody DN30

An awesome number of experimental and clinical evidences indicate that constitutive activation of the Met oncogenic receptor plays a critical role in the progression of cancer toward metastasis and/or resistance to targeted therapies. While mutations are rare, the common mechanism of Met activation...

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Bibliografiska uppgifter
I publikationen:Mol Oncol
Huvudupphovsmän: Vigna, Elisa, Chiriaco, Cristina, Cignetto, Simona, Fontani, Lara, Basilico, Cristina, Petronzelli, Fiorella, Comoglio, Paolo M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2015
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528712/
https://ncbi.nlm.nih.gov/pubmed/26119717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.05.007
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