Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours

BACKGROUND: Interferon-induced expression of programmed cell death ligands (PD-L1/PD-L2) may sustain tumour immune-evasion. Patients featuring MET amplification, a genetic lesion driving transformation, may benefit from anti-MET treatment. We explored if MET-targeted therapy interferes with Interfer...

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Publicado en:Br J Cancer
Main Authors: Martin, Valentina, Chiriaco, Cristina, Modica, Chiara, Acquadro, Anna, Cortese, Marco, Galimi, Francesco, Perera, Timothy, Gammaitoni, Loretta, Aglietta, Massimo, Comoglio, Paolo M., Vigna, Elisa, Sangiolo, Dario
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461865/
https://ncbi.nlm.nih.gov/pubmed/30723303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0315-3
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