A receptor-antibody hybrid hampering MET-driven metastatic spread

BACKGROUND: The receptor encoded by the MET oncogene and its ligand Hepatocyte Growth Factor (HGF) are at the core of the invasive-metastatic behavior. In a number of instances genetic alterations result in ligand-independent onset of malignancy (MET addiction). More frequently, ligand stimulation o...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Exp Clin Cancer Res
Auteurs principaux: Modica, Chiara, Basilico, Cristina, Chiriaco, Cristina, Borrelli, Nicla, Comoglio, Paolo M., Vigna, Elisa
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2021
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7807714/
https://ncbi.nlm.nih.gov/pubmed/33446252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01822-5
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