Increase of MET gene copy number confers resistance to a monovalent MET antibody and establishes drug dependence

The relevant role in cancer played by the tyrosine kinase receptor encoded by the MET oncogene led to the development of specific inhibitors, some of which are now in advanced phases of clinical trials. Previous experience has shown that the main limit to the efficacy of most targeted treatments is...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Oncol
Prif Awduron: Martin, Valentina, Corso, Simona, Comoglio, Paolo M., Giordano, Silvia
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2014
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528600/
https://ncbi.nlm.nih.gov/pubmed/25011627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.06.010
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