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Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition

BACKGROUND: Gastric cancer is the second leading cause of cancer mortality in the world. The receptor tyrosine kinase MET is constitutively activated in many gastric cancers and its expression is strictly required for survival of some gastric cancer cells. Thus, MET is considered a good candidate fo...

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Detalhes bibliográficos
Main Authors: Corso, Simona, Ghiso, Elena, Cepero, Virna, Sierra, J Rafael, Migliore, Cristina, Bertotti, Andrea, Trusolino, Livio, Comoglio, Paolo M, Giordano, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892452/
https://ncbi.nlm.nih.gov/pubmed/20500904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-121
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