Site-specific cleavage of RNA by Fe(II).bleomycin.

Bleomycin is an antitumor agent whose activity has long been thought to derive from its ability to degrade DNA. Recent findings suggest that cellular RNA may be a therapeutically relevant locus. At micromolar concentrations, Fe(II)-bleomycin readily cleaved a Bacillus subtilis tRNAHis precursor in a...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Carter, B J, de Vroom, E, Long, E C, van der Marel, G A, van Boom, J H, Hecht, S M
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1990
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55167/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1701259/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.23.9373
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