Site-specific cleavage of RNA by Fe(II).bleomycin.

Bleomycin is an antitumor agent whose activity has long been thought to derive from its ability to degrade DNA. Recent findings suggest that cellular RNA may be a therapeutically relevant locus. At micromolar concentrations, Fe(II)-bleomycin readily cleaved a Bacillus subtilis tRNAHis precursor in a...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Carter, B J, de Vroom, E, Long, E C, van der Marel, G A, van Boom, J H, Hecht, S M
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1990
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55167/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1701259/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.23.9373
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