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Site-specific cleavage of RNA by Fe(II).bleomycin.

Bleomycin is an antitumor agent whose activity has long been thought to derive from its ability to degrade DNA. Recent findings suggest that cellular RNA may be a therapeutically relevant locus. At micromolar concentrations, Fe(II)-bleomycin readily cleaved a Bacillus subtilis tRNAHis precursor in a...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Carter, B J, de Vroom, E, Long, E C, van der Marel, G A, van Boom, J H, Hecht, S M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55167/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1701259/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.23.9373
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