On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires

Cas1 integrase is the key enzyme of the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas adaptation module that mediates acquisition of spacers derived from foreign DNA by CRISPR arrays. In diverse bacteria, the cas1 gene is fused (or adjacent) to a gene encoding a reverse trans...

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Bibliografiske detaljer
Udgivet i:mBio
Main Authors: Silas, Sukrit, Makarova, Kira S., Shmakov, Sergey, Páez-Espino, David, Mohr, Georg, Liu, Yi, Davison, Michelle, Roux, Simon, Krishnamurthy, Siddharth R., Fu, Becky Xu Hua, Hansen, Loren L., Wang, David, Sullivan, Matthew B., Millard, Andrew, Clokie, Martha R., Bhaya, Devaki, Lambowitz, Alan M., Kyrpides, Nikos C., Koonin, Eugene V., Fire, Andrew Z.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5513706/
https://ncbi.nlm.nih.gov/pubmed/28698278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00897-17
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