The CRISPR Spacer Space Is Dominated by Sequences from Species-Specific Mobilomes

Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein (CRISPR-Cas) systems store the memory of past encounters with foreign DNA in unique spacers that are inserted between direct repeats in CRISPR arrays. For only a small fraction of the spacers, homologous sequence...

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Pubblicato in:mBio
Autori principali: Shmakov, Sergey A., Sitnik, Vassilii, Makarova, Kira S., Wolf, Yuri I., Severinov, Konstantin V., Koonin, Eugene V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605939/
https://ncbi.nlm.nih.gov/pubmed/28928211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01397-17
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