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Systematic prediction of genes functionally linked to CRISPR-Cas systems by gene neighborhood analysis

The CRISPR-Cas systems of bacterial and archaeal adaptive immunity consist of direct repeat arrays separated by unique spacers and multiple CRISPR-associated (cas) genes encoding proteins that mediate all stages of the CRISPR response. In addition to the relatively small set of core cas genes that a...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Shmakov, Sergey A., Makarova, Kira S., Wolf, Yuri I., Severinov, Konstantin V., Koonin, Eugene V.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003329/
https://ncbi.nlm.nih.gov/pubmed/29784811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803440115
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