On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires

Cas1 integrase is the key enzyme of the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas adaptation module that mediates acquisition of spacers derived from foreign DNA by CRISPR arrays. In diverse bacteria, the cas1 gene is fused (or adjacent) to a gene encoding a reverse trans...

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Vydáno v:mBio
Hlavní autoři: Silas, Sukrit, Makarova, Kira S., Shmakov, Sergey, Páez-Espino, David, Mohr, Georg, Liu, Yi, Davison, Michelle, Roux, Simon, Krishnamurthy, Siddharth R., Fu, Becky Xu Hua, Hansen, Loren L., Wang, David, Sullivan, Matthew B., Millard, Andrew, Clokie, Martha R., Bhaya, Devaki, Lambowitz, Alan M., Kyrpides, Nikos C., Koonin, Eugene V., Fire, Andrew Z.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5513706/
https://ncbi.nlm.nih.gov/pubmed/28698278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00897-17
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