On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires

Cas1 integrase is the key enzyme of the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas adaptation module that mediates acquisition of spacers derived from foreign DNA by CRISPR arrays. In diverse bacteria, the cas1 gene is fused (or adjacent) to a gene encoding a reverse trans...

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Pubblicato in:mBio
Autori principali: Silas, Sukrit, Makarova, Kira S., Shmakov, Sergey, Páez-Espino, David, Mohr, Georg, Liu, Yi, Davison, Michelle, Roux, Simon, Krishnamurthy, Siddharth R., Fu, Becky Xu Hua, Hansen, Loren L., Wang, David, Sullivan, Matthew B., Millard, Andrew, Clokie, Martha R., Bhaya, Devaki, Lambowitz, Alan M., Kyrpides, Nikos C., Koonin, Eugene V., Fire, Andrew Z.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5513706/
https://ncbi.nlm.nih.gov/pubmed/28698278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00897-17
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