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Prions amplify through degradation of the VPS10P sorting receptor sortilin
Prion diseases are a group of fatal neurodegenerative disorders caused by prions, which consist mainly of the abnormally folded isoform of prion protein, PrP(Sc). A pivotal pathogenic event in prion disease is progressive accumulation of prions, or PrP(Sc), in brains through constitutive conformatio...
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| Publicado en: | PLoS Pathog |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5509376/ https://ncbi.nlm.nih.gov/pubmed/28665987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006470 |
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