Prion Protein Devoid of the Octapeptide Repeat Region Delays Bovine Spongiform Encephalopathy Pathogenesis in Mice

Conformational conversion of the cellular isoform of prion protein, PrP(C), into the abnormally folded, amyloidogenic isoform, PrP(Sc), is a key pathogenic event in prion diseases, including Creutzfeldt-Jakob disease in humans and scrapie and bovine spongiform encephalopathy (BSE) in animals. We pre...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Hara, Hideyuki, Miyata, Hironori, Das, Nandita Rani, Chida, Junji, Yoshimochi, Tatenobu, Uchiyama, Keiji, Watanabe, Hitomi, Kondoh, Gen, Yokoyama, Takashi, Sakaguchi, Suehiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Prions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730770/
https://ncbi.nlm.nih.gov/pubmed/29046443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01368-17
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