Prion Protein Devoid of the Octapeptide Repeat Region Delays Bovine Spongiform Encephalopathy Pathogenesis in Mice

Conformational conversion of the cellular isoform of prion protein, PrP(C), into the abnormally folded, amyloidogenic isoform, PrP(Sc), is a key pathogenic event in prion diseases, including Creutzfeldt-Jakob disease in humans and scrapie and bovine spongiform encephalopathy (BSE) in animals. We pre...

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Detalles Bibliográficos
Publicado en:J Virol
Autores principales: Hara, Hideyuki, Miyata, Hironori, Das, Nandita Rani, Chida, Junji, Yoshimochi, Tatenobu, Uchiyama, Keiji, Watanabe, Hitomi, Kondoh, Gen, Yokoyama, Takashi, Sakaguchi, Suehiro
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2017
Materias:
Prions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730770/
https://ncbi.nlm.nih.gov/pubmed/29046443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01368-17
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