Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91–106

Conformational conversion of the cellular prion protein, PrP(C), into the abnormally folded isoform, PrP(Sc), is a key pathogenic event in prion diseases. However, the exact conversion mechanism remains largely unknown. Transgenic mice expressing PrP with a deletion of the central residues 91–106 we...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Uchiyama, Keiji, Miyata, Hironori, Yamaguchi, Yoshitaka, Imamura, Morikazu, Okazaki, Mariya, Pasiana, Agriani Dini, Chida, Junji, Hara, Hideyuki, Atarashi, Ryuichiro, Watanabe, Hitomi, Kondoh, Gen, Sakaguchi, Suehiro
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7582732/
https://ncbi.nlm.nih.gov/pubmed/33019549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21197260
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