Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells

Misfolding of the cellular prion protein, PrP(C), into the amyloidogenic isoform, PrP(Sc), which forms infectious protein aggregates, the so-called prions, is a key pathogenic event in prion diseases. No pathogens other than prions have been identified to induce misfolding of PrP(C) into PrP(Sc) and...

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Udgivet i:Sci Rep
Main Authors: Hara, Hideyuki, Chida, Junji, Uchiyama, Keiji, Pasiana, Agriani Dini, Takahashi, Etsuhisa, Kido, Hiroshi, Sakaguchi, Suehiro
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115602/
https://ncbi.nlm.nih.gov/pubmed/33980968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89586-6
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