Mouse-Hamster Chimeric Prion Protein (PrP) Devoid of N-Terminal Residues 23-88 Restores Susceptibility to 22L Prions, but Not to RML Prions in PrP-Knockout Mice

Prion infection induces conformational conversion of the normal prion protein PrP(C), into the pathogenic isoform PrP(Sc), in prion diseases. It has been shown that PrP-knockout (Prnp(0/0)) mice transgenically reconstituted with a mouse-hamster chimeric PrP lacking N-terminal residues 23-88, or Tg(M...

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Main Authors: Uchiyama, Keiji, Miyata, Hironori, Yano, Masashi, Yamaguchi, Yoshitaka, Imamura, Morikazu, Muramatsu, Naomi, Das, Nandita Rani, Chida, Junji, Hara, Hideyuki, Sakaguchi, Suehiro
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199594/
https://ncbi.nlm.nih.gov/pubmed/25330286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109737
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