Propagation of RML Prions in Mice Expressing PrP Devoid of GPI Anchor Leads to Formation of a Novel, Stable Prion Strain

PrP(C), a host protein which in prion-infected animals is converted to PrP(Sc), is linked to the cell membrane by a GPI anchor. Mice expressing PrP(C) without GPI anchor (tgGPI(-) mice), are susceptible to prion infection but accumulate anchorless PrP(Sc) extra-, rather than intracellularly. We inve...

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Hlavní autoři: Mahal, Sukhvir Paul, Jablonski, Joseph, Suponitsky-Kroyter, Irena, Oelschlegel, Anja Maria, Herva, Maria Eugenia, Oldstone, Michael, Weissmann, Charles
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369955/
https://ncbi.nlm.nih.gov/pubmed/22685404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002746
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