Biological and Biochemical Characterization of Mice Expressing Prion Protein Devoid of the Octapeptide Repeat Region after Infection with Prions

Accumulating lines of evidence indicate that the N-terminal domain of prion protein (PrP) is involved in prion susceptibility in mice. In this study, to investigate the role of the octapeptide repeat (OR) region alone in the N-terminal domain for the susceptibility and pathogenesis of prion disease,...

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Main Authors: Yamaguchi, Yoshitaka, Miyata, Hironori, Uchiyama, Keiji, Ootsuyama, Akira, Inubushi, Sachiko, Mori, Tsuyoshi, Muramatsu, Naomi, Katamine, Shigeru, Sakaguchi, Suehiro
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424169/
https://ncbi.nlm.nih.gov/pubmed/22927985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043540
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