Dominant-negative Effects of the N-terminal Half of Prion Protein on Neurotoxicity of Prion Protein-like Protein/Doppel in Mice

Prion protein-like protein/doppel is neurotoxic, causing ataxia and Purkinje cell degeneration in mice, whereas prion protein antagonizes doppel-induced neurodegeneration. Doppel is homologous to the C-terminal half of prion protein but lacks the amino acid sequences corresponding to the N-terminal...

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Detalhes bibliográficos
Main Authors: Yoshikawa, Daisuke, Yamaguchi, Naohiro, Ishibashi, Daisuke, Yamanaka, Hitoki, Okimura, Nobuhiko, Yamaguchi, Yoshitaka, Mori, Tsuyoshi, Miyata, Hironori, Shigematsu, Kazuto, Katamine, Shigeru, Sakaguchi, Suehiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259768/
https://ncbi.nlm.nih.gov/pubmed/18562311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804212200
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