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Abnormal activation of glial cells in the brains of prion protein-deficient mice ectopically expressing prion protein-like protein, PrPLP/Dpl.

BACKGROUND: Some lines of mice homozygous for a disrupted prion protein gene (Prnp), including Ngsk Prnp(0/0) mice, exhibit Purkinje cell degeneration as a consequence of the ectopic overexpression of the downstream gene for prion protein-like protein (PrPLP/Dpl) in the brain, but others, such as Zr...

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Main Authors: Atarashi, R., Sakaguchi, S., Shigematsu, K., Arima, K., Okimura, N., Yamaguchi, N., Li, A., Kopacek, J., Katamine, S.
Format: Artigo
Jezik:Inglês
Izdano: 2001
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950009/
https://ncbi.nlm.nih.gov/pubmed/11844868
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