Impairment of cerebellar long-term depression and GABAergic transmission in prion protein deficient mice ectopically expressing PrPLP/Dpl

Prion protein (PrP(C)) knockout mice, named as the “Ngsk” strain (Ngsk Prnp(0/0) mice), show late-onset cerebellar Purkinje cell (PC) degeneration because of ectopic overexpression of PrP(C)-like protein (PrPLP/Dpl). Our previous study indicated that the mutant mice also exhibited alterations in cer...

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Publicado no:Sci Rep
Main Authors: Kishimoto, Yasushi, Hirono, Moritoshi, Atarashi, Ryuichiro, Sakaguchi, Suehiro, Yoshioka, Tohru, Katamine, Shigeru, Kirino, Yutaka
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7522223/
https://ncbi.nlm.nih.gov/pubmed/32985542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72753-6
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