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Impairment of cerebellar long-term depression and GABAergic transmission in prion protein deficient mice ectopically expressing PrPLP/Dpl
Prion protein (PrP(C)) knockout mice, named as the “Ngsk” strain (Ngsk Prnp(0/0) mice), show late-onset cerebellar Purkinje cell (PC) degeneration because of ectopic overexpression of PrP(C)-like protein (PrPLP/Dpl). Our previous study indicated that the mutant mice also exhibited alterations in cer...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7522223/ https://ncbi.nlm.nih.gov/pubmed/32985542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72753-6 |
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