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Prion Strain-Dependent Differences in Conversion of Mutant Prion Proteins in Cell Culture
Although the protein-only hypothesis proposes that it is the conformation of abnormal prion protein (PrP(Sc)) that determines strain diversity, the molecular basis of strains remains to be elucidated. In the present study, we generated a series of mutations in the normal prion protein (PrP(C)) in wh...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2006
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1563786/ https://ncbi.nlm.nih.gov/pubmed/16873242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00424-06 |
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