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Antagonistic roles of the N-terminal domain of prion protein to doppel

Prion protein (PrP)-like molecule, doppel (Dpl), is neurotoxic in mice, causing Purkinje cell degeneration. In contrast, PrP antagonizes Dpl in trans, rescuing mice from Purkinje cell death. We have previously shown that PrP with deletion of the N-terminal residues 23–88 failed to neutralize Dpl in...

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Detalles Bibliográficos
Autor Principal: Sakaguchi, Suehiro
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634528/
https://ncbi.nlm.nih.gov/pubmed/19158506
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