Melanin or a Melanin-Like Substance Interacts with the N-Terminal Portion of Prion Protein and Inhibits Abnormal Prion Protein Formation in Prion-Infected Cells

Prion diseases are progressive fatal neurodegenerative illnesses caused by the accumulation of transmissible abnormal prion protein (PrP). To find treatments for prion diseases, we searched for substances from natural resources that inhibit abnormal PrP formation in prion-infected cells. We found th...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Hamanaka, Taichi, Nishizawa, Keiko, Sakasegawa, Yuji, Oguma, Ayumi, Teruya, Kenta, Kurahashi, Hiroshi, Hara, Hideyuki, Sakaguchi, Suehiro, Doh-ura, Katsumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Prions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331829/
https://ncbi.nlm.nih.gov/pubmed/28077650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01862-16
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