Melanin or a Melanin-Like Substance Interacts with the N-Terminal Portion of Prion Protein and Inhibits Abnormal Prion Protein Formation in Prion-Infected Cells

Prion diseases are progressive fatal neurodegenerative illnesses caused by the accumulation of transmissible abnormal prion protein (PrP). To find treatments for prion diseases, we searched for substances from natural resources that inhibit abnormal PrP formation in prion-infected cells. We found th...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Hamanaka, Taichi, Nishizawa, Keiko, Sakasegawa, Yuji, Oguma, Ayumi, Teruya, Kenta, Kurahashi, Hiroshi, Hara, Hideyuki, Sakaguchi, Suehiro, Doh-ura, Katsumi
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2017
Sujets:
Prions
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331829/
https://ncbi.nlm.nih.gov/pubmed/28077650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01862-16
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