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Novel amplification mechanism of prions through disrupting sortilin-mediated trafficking
Conformational conversion of the cellular prion protein, PrP(C), into the abnormally folded isoform of prion protein, PrP(Sc), which leads to marked accumulation of PrP(Sc) in brains, is a key pathogenic event in prion diseases, a group of fatal neurodegenerative disorders caused by prions. However,...
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| Udgivet i: | Prion |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5786358/ https://ncbi.nlm.nih.gov/pubmed/29099278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336896.2017.1391435 |
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