Prions amplify through degradation of the VPS10P sorting receptor sortilin

Prion diseases are a group of fatal neurodegenerative disorders caused by prions, which consist mainly of the abnormally folded isoform of prion protein, PrP(Sc). A pivotal pathogenic event in prion disease is progressive accumulation of prions, or PrP(Sc), in brains through constitutive conformatio...

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Publicat a:PLoS Pathog
Autors principals: Uchiyama, Keiji, Tomita, Mitsuru, Yano, Masashi, Chida, Junji, Hara, Hideyuki, Das, Nandita Rani, Nykjaer, Anders, Sakaguchi, Suehiro
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509376/
https://ncbi.nlm.nih.gov/pubmed/28665987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006470
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