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Transition State Structure of RNA Depurination by Saporin L3

Saporin L3 from the leaves of the common soapwort is a catalyst for hydrolytic depurination of adenine from RNA. Saporin L3 is a type 1 ribosome inactivating protein (RIP) composed only of a catalytic domain. Other RIPs have been used in immunotoxin cancer therapy, but off-target effects have limite...

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Pubblicato in:ACS Chem Biol
Autori principali: Yuan, Hongling, Stratton, Christopher F., Schramm, Vern L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502533/
https://ncbi.nlm.nih.gov/pubmed/26886255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b01069
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