Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer

A hierarchically organized cell compartment drives colorectal cancer (CRC) progression. Genetic barcoding allows monitoring of the clonal output of tumorigenic cells without prospective isolation. In this study, we asked whether tumor clone-initiating cells (TcICs) were genetically heterogeneous and...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Exp Med
Auteurs principaux: Giessler, Klara M., Kleinheinz, Kortine, Huebschmann, Daniel, Balasubramanian, Gnana Prakash, Dubash, Taronish D., Dieter, Sebastian M., Siegl, Christine, Herbst, Friederike, Weber, Sarah, Hoffmann, Christopher M., Fronza, Raffaele, Buchhalter, Ivo, Paramasivam, Nagarajan, Eils, Roland, Schmidt, Manfred, von Kalle, Christof, Schneider, Martin, Ulrich, Alexis, Scholl, Claudia, Fröhling, Stefan, Weichert, Wilko, Brors, Benedikt, Schlesner, Matthias, Ball, Claudia R., Glimm, Hanno
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2017
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502434/
https://ncbi.nlm.nih.gov/pubmed/28572216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20162017
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires