The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo

BACKGROUND: While colorectal cancer (CRC) patients with localized disease have a favorable prognosis, the five-year-survival rate in patients with distant spread is still below 15%. Hence, a detailed understanding of the mechanisms regulating metastasis formation is essential to develop therapeutic...

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Pubblicato in:BMC Cancer
Autori principali: Weber, Sarah, Koschade, Sebastian E., Hoffmann, Christopher M., Dubash, Taronish D., Giessler, Klara M., Dieter, Sebastian M., Herbst, Friederike, Glimm, Hanno, Ball, Claudia R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892194/
https://ncbi.nlm.nih.gov/pubmed/31796022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-6396-4
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