Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer

A hierarchically organized cell compartment drives colorectal cancer (CRC) progression. Genetic barcoding allows monitoring of the clonal output of tumorigenic cells without prospective isolation. In this study, we asked whether tumor clone-initiating cells (TcICs) were genetically heterogeneous and...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Giessler, Klara M., Kleinheinz, Kortine, Huebschmann, Daniel, Balasubramanian, Gnana Prakash, Dubash, Taronish D., Dieter, Sebastian M., Siegl, Christine, Herbst, Friederike, Weber, Sarah, Hoffmann, Christopher M., Fronza, Raffaele, Buchhalter, Ivo, Paramasivam, Nagarajan, Eils, Roland, Schmidt, Manfred, von Kalle, Christof, Schneider, Martin, Ulrich, Alexis, Scholl, Claudia, Fröhling, Stefan, Weichert, Wilko, Brors, Benedikt, Schlesner, Matthias, Ball, Claudia R., Glimm, Hanno
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502434/
https://ncbi.nlm.nih.gov/pubmed/28572216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20162017
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