Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer

A hierarchically organized cell compartment drives colorectal cancer (CRC) progression. Genetic barcoding allows monitoring of the clonal output of tumorigenic cells without prospective isolation. In this study, we asked whether tumor clone-initiating cells (TcICs) were genetically heterogeneous and...

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發表在:J Exp Med
Main Authors: Giessler, Klara M., Kleinheinz, Kortine, Huebschmann, Daniel, Balasubramanian, Gnana Prakash, Dubash, Taronish D., Dieter, Sebastian M., Siegl, Christine, Herbst, Friederike, Weber, Sarah, Hoffmann, Christopher M., Fronza, Raffaele, Buchhalter, Ivo, Paramasivam, Nagarajan, Eils, Roland, Schmidt, Manfred, von Kalle, Christof, Schneider, Martin, Ulrich, Alexis, Scholl, Claudia, Fröhling, Stefan, Weichert, Wilko, Brors, Benedikt, Schlesner, Matthias, Ball, Claudia R., Glimm, Hanno
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2017
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Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502434/
https://ncbi.nlm.nih.gov/pubmed/28572216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20162017
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