Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer

A hierarchically organized cell compartment drives colorectal cancer (CRC) progression. Genetic barcoding allows monitoring of the clonal output of tumorigenic cells without prospective isolation. In this study, we asked whether tumor clone-initiating cells (TcICs) were genetically heterogeneous and...

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Bibliografische gegevens
Gepubliceerd in:J Exp Med
Hoofdauteurs: Giessler, Klara M., Kleinheinz, Kortine, Huebschmann, Daniel, Balasubramanian, Gnana Prakash, Dubash, Taronish D., Dieter, Sebastian M., Siegl, Christine, Herbst, Friederike, Weber, Sarah, Hoffmann, Christopher M., Fronza, Raffaele, Buchhalter, Ivo, Paramasivam, Nagarajan, Eils, Roland, Schmidt, Manfred, von Kalle, Christof, Schneider, Martin, Ulrich, Alexis, Scholl, Claudia, Fröhling, Stefan, Weichert, Wilko, Brors, Benedikt, Schlesner, Matthias, Ball, Claudia R., Glimm, Hanno
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2017
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502434/
https://ncbi.nlm.nih.gov/pubmed/28572216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20162017
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