Evolution of a FLT3-TKD mutated subclone at meningeal relapse in acute promyelocytic leukemia

Here, we report the case of an acute promyelocytic leukemia (APL) patient who—although negative for FLT3 mutations at diagnosis—developed isolated FLT3 tyrosine kinase II domain (FLT3-TKD)-positive meningeal relapse, which, in retrospect, could be traced back to a minute bone marrow subclone present...

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Detalhes bibliográficos
Publicado no:Cold Spring Harb Mol Case Stud
Main Authors: Bochtler, Tilmann, Fröhling, Stefan, Weichert, Wilko, Endris, Volker, Thiede, Christian, Hutter, Barbara, Hundemer, Michael, Ho, Anthony D., Krämer, Alwin
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5002926/
https://ncbi.nlm.nih.gov/pubmed/27626069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a001123
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