Evolution of a FLT3-TKD mutated subclone at meningeal relapse in acute promyelocytic leukemia

Here, we report the case of an acute promyelocytic leukemia (APL) patient who—although negative for FLT3 mutations at diagnosis—developed isolated FLT3 tyrosine kinase II domain (FLT3-TKD)-positive meningeal relapse, which, in retrospect, could be traced back to a minute bone marrow subclone present...

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Dettagli Bibliografici
Pubblicato in:Cold Spring Harb Mol Case Stud
Autori principali: Bochtler, Tilmann, Fröhling, Stefan, Weichert, Wilko, Endris, Volker, Thiede, Christian, Hutter, Barbara, Hundemer, Michael, Ho, Anthony D., Krämer, Alwin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2016
Soggetti:
Research Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5002926/
https://ncbi.nlm.nih.gov/pubmed/27626069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a001123
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