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Pyrazinoic Acid Inhibits a Bifunctional Enzyme in Mycobacterium tuberculosis
Pyrazinamide (PZA), an indispensable component of modern tuberculosis treatment, acts as a key sterilizing drug. While the mechanism of activation of this prodrug into pyrazinoic acid (POA) by Mycobacterium tuberculosis has been extensively studied, not all molecular determinants that confer resista...
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| Vydáno v: | Antimicrob Agents Chemother |
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| Hlavní autoři: | , , , , , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5487608/ https://ncbi.nlm.nih.gov/pubmed/28438933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00070-17 |
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