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Pyrazinoic Acid Inhibits a Bifunctional Enzyme in Mycobacterium tuberculosis

Pyrazinamide (PZA), an indispensable component of modern tuberculosis treatment, acts as a key sterilizing drug. While the mechanism of activation of this prodrug into pyrazinoic acid (POA) by Mycobacterium tuberculosis has been extensively studied, not all molecular determinants that confer resista...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Njire, Moses, Wang, Na, Wang, Bangxing, Tan, Yaoju, Cai, Xingshan, Liu, Yanwen, Mugweru, Julius, Guo, Jintao, Hameed, H. M. Adnan, Tan, Shouyong, Liu, Jianxiong, Yew, Wing Wai, Nuermberger, Eric, Lamichhane, Gyanu, Liu, Jinsong, Zhang, Tianyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487608/
https://ncbi.nlm.nih.gov/pubmed/28438933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00070-17
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