Pyrazinoic Acid Inhibits a Bifunctional Enzyme in Mycobacterium tuberculosis

Pyrazinamide (PZA), an indispensable component of modern tuberculosis treatment, acts as a key sterilizing drug. While the mechanism of activation of this prodrug into pyrazinoic acid (POA) by Mycobacterium tuberculosis has been extensively studied, not all molecular determinants that confer resista...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Njire, Moses, Wang, Na, Wang, Bangxing, Tan, Yaoju, Cai, Xingshan, Liu, Yanwen, Mugweru, Julius, Guo, Jintao, Hameed, H. M. Adnan, Tan, Shouyong, Liu, Jianxiong, Yew, Wing Wai, Nuermberger, Eric, Lamichhane, Gyanu, Liu, Jinsong, Zhang, Tianyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487608/
https://ncbi.nlm.nih.gov/pubmed/28438933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00070-17
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